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1

Obesity, Fat Mass and Immune System: Role for Leptin

Francisco, Vera, Pino, Jesús, Campos-Cabaleiro, Victor, Ruiz-Fernández, Clara, Mera, Antonio, Gonzalez-Gay, Miguel A., Gómez, Rodolfo, Gualillo, Oreste

Journal:

Frontiers in Physiology

Year:

2018

Language:

english

File:

PDF, 3.26 MB

english, 2018

2

Adipokines: Biofactors from white adipose tissue. A complex hub among inflammation, metabolism, and immunity

Javier Conde, Morena Scotece, Rodolfo Gómez, Verónica López, Juan Jesús Gómez-Reino, Francisca Lago, Oreste Gualillo

Journal:

Year:

2011

Language:

english

File:

PDF, 226 KB

english, 2011

3

New drugs from ancient natural foods. Oleocanthal, the natural occurring spicy compound of olive oil: a brief history

Scotece, Morena, Conde, Javier, Abella, Vanessa, Lopez, Veronica, Pino, Jesús, Lago, Francisca, Smith, Amos B., Gómez-Reino, Juan J., Gualillo, Oreste

Journal:

Drug Discovery Today

Year:

2015

Language:

english

File:

PDF, 1.00 MB

english, 2015

4

Ghrelin, A Novel Placental-Derived Hormone 1

Gualillo, Oreste, Caminos, J. Eduardo, Blanco, Montserrat, Garcìa-Caballero, Tomas, Kojima, Masayasu, Kangawa, Kenji, Dieguez, Carlos, Casanueva, Felipe F.

Journal:

Year:

2001

Language:

english

File:

PDF, 493 KB

english, 2001

5

Mediators of Inflammation in Obesity and Its Comorbidities

Gualillo, Oreste

Journal:

Mediators of Inflammation

Year:

2010

Language:

english

File:

PDF, 47 KB

english, 2010

6

The role of metabolism in the pathogenesis of osteoarthritis

Mobasheri, Ali, Rayman, Margaret P., Gualillo, Oreste, Sellam, Jérémie, van der Kraan, Peter, Fearon, Ursula

Journal:

Nature Reviews Rheumatology (formerly Nature Clinical Practice Rheumatology)

Year:

2017

Language:

english

File:

PDF, 464 KB

english, 2017

7

Molecular taxonomy of osteoarthritis for patient stratification, disease management and drug development

Mobasheri, Ali, van Spil, Willem Evert, Budd, Emma, Uzieliene, Ilona, Bernotiene, Eiva, Bay-Jensen, Anne-Christine, Larkin, Jonathan, Levesque, Marc C., Gualillo, Oreste, Henrotin, Yves

Journal:

Current Opinion in Rheumatology

Year:

2019

Language:

english

File:

PDF, 655 KB

english, 2019

8

Cardiometabolic comorbidities and rheumatic diseases: Focus on the role of fat mass and adipokines

Francisca Lago, Rodolfo Gómez, Javier Conde, Morena Scotece, Juan Jesus Gómez-Reino, Oreste Gualillo

Journal:

Arthritis Care & Research

Year:

2011

Language:

english

File:

PDF, 182 KB

english, 2011

9

Synergistic induction of nitric oxide synthase type II: In vitro effect of leptin and interferon-γ in human chondrocytes and ATDC5 chondrogenic cells

Miguel Otero, Juan Jesús Gomez Reino, Oreste Gualillo

Journal:

Arthritis & Rheumatism

Year:

2003

Language:

english

File:

PDF, 133 KB

english, 2003

10

Expression and modulation of ghrelin O-acyltransferase in cultured chondrocytes

Rodolfo Gómez, Francisca Lago, Juan J. Gómez-Reino, Carlos Dieguez, Oreste Gualillo

Journal:

Arthritis & Rheumatism

Year:

2009

Language:

english

File:

PDF, 178 KB

english, 2009

11

Effect of oleocanthal and its derivatives on inflammatory response induced by lipopolysaccharide in a murine chondrocyte cell line

Anna Iacono, Rodolfo Gómez, Jeffrey Sperry, Javier Conde, Giuseppe Bianco, Rosaria Meli, Juan J. Gómez-Reino, Amos B. Smith III, Oreste Gualillo

Journal:

Arthritis & Rheumatism

Year:

2010

Language:

english

File:

PDF, 310 KB

english, 2010

12

Leptin inhibits lysophosphatidic acid-induced intracellular calcium rise by a protein kinase C-dependent mechanism

Sonia Eiras, Jesus P. Camiña, Esther Diaz-Rodriguez, Oreste Gualillo, Felipe F. Casanueva

Journal:

Journal of Cellular Physiology

Year:

2004

Language:

english

File:

PDF, 392 KB

english, 2004

13

Prolactin Induction of Nitric Oxide Synthase in Rat C6 Glioma Cells

Giuseppina Mattace Raso, Rosaria Meli, Oreste Gualillo, Maria Pacilio, Raffaele Di Carlo

Journal:

Journal of Neurochemistry

Year:

1999

Language:

english

File:

PDF, 135 KB

english, 1999

14

Ghrelin plasmatic levels in patients with fibromyalgia

Miguel Otero, Ruben Nogueiras, Francisca Lago, Juan Meijide, Juan Amarelo, Antonio Mera, Juan Gomez-Reino, Oreste Gualillo

Journal:

Rheumatology International

Year:

2005

Language:

english

File:

PDF, 156 KB

english, 2005

15

Effect of Food Restriction on Ghrelin in Normal-Cycling Female Rats and in Pregnancy

Oreste Gualillo, Jorge E. Caminos, Rubén Nogueiras, Luisa M. Seoane, Eva Arvat, Ezio Ghigo, Felipe F. Casanueva, Dr. Carlos Diéguez

Journal:

Year:

2002

Language:

english

File:

PDF, 154 KB

english, 2002

16

Regulation of Resistin by Gonadal, Thyroid Hormone, and Nutritional Status

Rubén Nogueiras, Oreste Gualillo, J. Eduardo Caminos, Felipe F. Casanueva, Carlos Diéguez

Journal:

Year:

2003

Language:

english

File:

PDF, 197 KB

english, 2003

17

Differential Effects of Age and Sex on the Postnatal Responsiveness of Brown Adipose Tissue to Prolactin Administration in Rats

Sarah Pearce, Carlos Dieguez, Oreste Gualillo, Michael E. Symonds, Terence Stephenson

Journal:

Experimental Physiology

Year:

2003

Language:

english

File:

PDF, 119 KB

english, 2003

18

Growth hormone secretagogues as diagnostic tools in disease states

Roberto Baldelli, Xose L. Otero, Jesus P. Camiña, Oreste Gualillo, Vera Popovic, Carlos Dieguez, Felipe F. Casanueva

Journal:

Endocrine (Springer)

Year:

2001

Language:

english

File:

PDF, 96 KB

english, 2001

19

Aliskiren affects fatty-acid uptake and lipid-related genes in rodent and human cardiomyocytes

Diego Rodríguez-Penas, Sandra Feijóo-Bandín, Pamela V. Lear, Ana Mosquera-Leal, Vanessa García-Rúa, Manuel F. Otero, Miguel Rivera, Oreste Gualillo, José Ramón González-Juanatey, Francisca Lago

Journal:

Biochemical Pharmacology

Year:

2011

Language:

english

File:

PDF, 2.00 MB

english, 2011

20

Leptin beyond body weight regulation—Current concepts concerning its role in immune function and inflammation

Rocío Lago, Rodolfo Gómez, Francisca Lago, Juan Gómez-Reino, Oreste Gualillo

Journal:

Cellular Immunology

Year:

2008

Language:

english

File:

PDF, 379 KB

english, 2008

21

The Emerging Role of Adipokines as Mediators of Cardiovascular Function: Physiologic and Clinical Perspectives

Oreste Gualillo, José Ramón González-Juanatey, Francisca Lago

Journal:

Trends in Cardiovascular Medicine

Year:

2007

Language:

english

File:

PDF, 583 KB

english, 2007

22

Adipokines as novel modulators of lipid metabolism

Francisca Lago, Rodolfo Gómez, Juan J. Gómez-Reino, Carlos Dieguez, Oreste Gualillo

Journal:

Trends in Biochemical Sciences

Year:

2009

Language:

english

File:

PDF, 380 KB

english, 2009

23

The emerging role of adipokines as mediators of inflammation and immune responses

Francisca Lago, Carlos Dieguez, Juan Gómez-Reino, Oreste Gualillo

Journal:

Cytokine & Growth Factor Reviews

Year:

2007

Language:

english

File:

PDF, 1.11 MB

english, 2007

24

Ghrelin: a metabolic signal affecting the reproductive system

Teresa Lorenzi, Rosaria Meli, Daniela Marzioni, Manrico Morroni, Alessandra Baragli, Mario Castellucci, Oreste Gualillo, Giampiero Muccioli

Journal:

Cytokine & Growth Factor Reviews

Year:

2009

Language:

english

File:

PDF, 723 KB

english, 2009

25

Leptin, from fat to inflammation: old questions and new insights

Miguel Otero, Rocı́o Lago, Francisca Lago, Felipe F. Casanueva, Carlos Dieguez, Juan Jesús Gómez-Reino, Oreste Gualillo

Journal:

Year:

2005

Language:

english

File:

PDF, 193 KB

english, 2005

26

Adiponectin is synthesized and secreted by human and murine cardiomyocytes

Roberto Piñeiro, María J. Iglesias, Rosalía Gallego, Kawtar Raghay, Sonia Eiras, José Rubio, Carlos Diéguez, Oreste Gualillo, José R. González-Juanatey, Francisca Lago

Journal:

Year:

2005

Language:

english

File:

PDF, 338 KB

english, 2005

27

Phosphatidylinositol 3-kinase, MEK-1 and p38 mediate leptin/interferon-gamma synergistic NOS type II induction in chondrocytes

Miguel Otero, Rocío Lago, Rodolfo Gómez, Francisca Lago, Juan Jesús Gomez-Reino, Oreste Gualillo

Journal:

Year:

2007

Language:

english

File:

PDF, 489 KB

english, 2007

28

One ancestor, several peptides: Post-translational modifications of preproghrelin generate several peptides with antithetical effects

Oreste Gualillo, Francisca Lago, Felipe F. Casanueva, Carlos Dieguez

Journal:

Molecular and Cellular Endocrinology

Year:

2006

Language:

english

File:

PDF, 258 KB

english, 2006

29

Beyond the metabolic role of ghrelin: A new player in the regulation of reproductive function

Giampiero Muccioli, Teresa Lorenzi, Maria Lorenzi, Corrado Ghè, Elisa Arnoletti, Giuseppina Mattace Raso, Mario Castellucci, Oreste Gualillo, Rosaria Meli

Journal:

Year:

2011

Language:

english

File:

PDF, 468 KB

english, 2011

30

Introducing GOAT: a target for obesity and anti-diabetic drugs?

Oreste Gualillo, Francisca Lago, Carlos Dieguez

Journal:

Trends in Pharmacological Sciences

Year:

2008

Language:

english

File:

PDF, 261 KB

english, 2008

31

Resistin is expressed in different rat tissues and is regulated in a tissue- and gender-specific manner

Rubén Nogueiras, Rosalı&amp, #x0301, a Gallego, Oreste Gualillo, J.Eduardo Caminos, Tomás Garcı&amp, #x0301, a-Caballero, Felipe F. Casanueva, Carlos Diéguez

Journal:

Year:

2003

Language:

english

File:

PDF, 591 KB

english, 2003

32

Ghrelin, a widespread hormone: insights into molecular and cellular regulation of its expression and mechanism of action

Oreste Gualillo, Francisca Lago, Juan Gómez-Reino, Felipe F Casanueva, Carlos Dieguez

Journal:

Year:

2003

Language:

english

File:

PDF, 151 KB

english, 2003

33

Elevated serum leptin concentrations induced by experimental acute inflammation

Oreste Gualillo, Sonia Eiras, Francisca Lago, Carlos Diéguez, Felipe F. Casanueva

Journal:

Year:

2000

Language:

english

File:

PDF, 278 KB

english, 2000

34

Prolactin modulation of nitric oxide and TNF-α production by peripheral neutrophils in rats

Rosaria Meli, Giuseppina Mattace Raso, Oreste Gualillo, Maria Pacilio, Taffaele Di Carlo

Journal:

Year:

1997

Language:

english

File:

PDF, 638 KB

english, 1997

35

Further evidence for the involvement of prolactin in the inflammatory response

Rosaria Meli, Oreste Gualillo, Giuseppina Mattace Raso, Raffaele Di Carlo

Journal:

Year:

1993

Language:

english

File:

PDF, 387 KB

english, 1993

36

Further evidence for the anti-inflammatory activity of oleocanthal: Inhibition of MIP-1α and IL-6 in J774 macrophages and in ATDC5 chondrocytes

Morena Scotece, Rodolfo Gómez, Javier Conde, Verónica Lopez, Juan J. Gómez-Reino, Francisca Lago, Amos B. Smith III, Oreste Gualillo

Journal:

Year:

2012

Language:

english

File:

PDF, 668 KB

english, 2012

37

1106-188 Ghrelin is synthesized and secreted by human cardiomyocytes protecting these cells from apoptosis

JoséRamón González-Juanatey, María J Iglesias, Roberto Piñeiro, Oreste Gualillo, Montserrat Blanco, Carlos Diéguez, Francisca Lago

Journal:

Journal of the American College of Cardiology

Year:

2004

Language:

english

File:

PDF, 63 KB

english, 2004

38

What's new in our understanding of the role of adipokines in rheumatic diseases?

Gómez, Rodolfo, Conde, Javier, Scotece, Morena, Gómez-Reino, Juan Jesus, Lago, Francisca, Gualillo, Oreste

Journal:

Nature Reviews Rheumatology (formerly Nature Clinical Practice Rheumatology)

Year:

2011

Language:

english

File:

PDF, 536 KB

english, 2011

39

Studies on Arthritis and Joint Disorders ||

Alcaraz, Maria Jose, Gualillo, Oreste, Sánchez-Pernaute, Olga

Year:

2013

Language:

english

File:

PDF, 5.35 MB

english, 2013

40

Studies on Arthritis and Joint Disorders || Oxidative Stress in Rheumatoid Arthritis

Alcaraz, Maria Jose, Gualillo, Oreste, Sánchez-Pernaute, Olga

Year:

2013

Language:

english

File:

PDF, 418 KB

english, 2013

41

Adipokines as drug targets in joint and bone disease

Scotece, Morena, Conde, Javier, Vuolteenaho, Katriina, Koskinen, Anna, López, Veronica, Gómez-Reino, Juan, Lago, Francisca, Moilanen, Eeva, Gualillo, Oreste

Journal:

Drug Discovery Today

Year:

2014

Language:

english

File:

PDF, 664 KB

english, 2014

42

At the crossroad between immunity and metabolism: focus on leptin

Conde, Javier, Scotece, Morena, Gómez, Rodolfo, Gómez-Reino, Juan J, Lago, Francisca, Gualillo, Oreste

Journal:

Expert Review of Clinical Immunology

Year:

2010

Language:

english

File:

PDF, 788 KB

english, 2010

43

6-Shogaol inhibits chondrocytes’ innate immune responses and cathepsin-K activity

Villalvilla, Amanda, da Silva, Jame's A., Largo, Raquel, Gualillo, Oreste, Vieira, Paulo Cezar, Herrero-Beaumont, Gabriel, Gómez, Rodolfo

Journal:

Molecular Nutrition & Food Research

Year:

2014

Language:

english

File:

PDF, 928 KB

english, 2014

44

Las adipocinas: mediadores emergentes de la respuesta inmune y de la inflamación

Gómez, Rodolfo, Conde, Javier, Gómez Reino, Juan J., Lago, Francisca, Gualillo, Oreste

Journal:

Reumatología Clínica

Year:

2009

File:

PDF, 317 KB

2009

45

Endogenous cannabinoid anandamide impairs cell growth and induces apoptosis in chondrocytes

Gómez, Rodolfo, Conde, Javier, Scotece, Morena, López, Verónica, Lago, Francisca, Gómez Reino, Juan Jesús, Gualillo, Oreste

Journal:

Journal of Orthopaedic Research

Year:

2014

Language:

english

File:

PDF, 344 KB

english, 2014

46

Nesfatin-1 in Human and Murine Cardiomyocytes: Synthesis, Secretion, and Mobilization of GLUT-4

Feijóo-Bandín, Sandra, Rodríguez-Penas, Diego, García-Rúa, Vanessa, Mosquera-Leal, Ana, Otero, Manuel Francisco, Pereira, Eva, Rubio, José, Martínez, Isabel, Seoane, Luisa María, Gualillo, Oreste, Cal

Journal:

Year:

2013

Language:

english

File:

PDF, 1.59 MB

english, 2013

47

Bone metabolism and adipokines: are there perspectives for bone diseases drug discovery?

Scotece, Morena, Conde, Javier, Abella, Vanessa, López, Verónica, Pino, Jesús, Lago, Francisca, Gómez-Reino, Juan J, Gualillo, Oreste

Journal:

Expert Opinion on Drug Discovery

Year:

2014

Language:

english

File:

PDF, 440 KB

english, 2014

48

An update on leptin as immunomodulator

Conde, Javier, Scotece, Morena, Abella, Vanessa, López, Verónica, Pino, Jesús, Gómez-Reino, Juan J, Gualillo, Oreste

Journal:

Expert Review of Clinical Immunology

Year:

2014

Language:

english

File:

PDF, 315 KB

english, 2014

49

Ghrelin Requires p53 to Stimulate Lipid Storage in Fat and Liver

Porteiro, Begoña, Díaz-Ruíz, Alberto, Martínez, Gloria, Senra, Ana, Vidal, Anxo, Serrano, Manuel, Gualillo, Oreste, López, Miguel, Malagón, María M., Diéguez, Carlos, Nogueiras, Rubén

Journal:

Year:

2013

Language:

english

File:

PDF, 1.74 MB

english, 2013

50

Adipokines as emerging mediators of immune response and inflammation

Lago, Francisca, Dieguez, Carlos, Gómez-Reino, Juan, Gualillo, Oreste

Journal:

Nature Clinical Practice Rheumatology

Year:

2007

Language:

english

File:

PDF, 1.07 MB

english, 2007

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